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父母年龄和儿童过敏风险
Kiwako Yamamoto-Hanada1, Daisuke Harama2, Miori Sato2
1Allergy Center, National Center for Child Health and Development, Tokyo, Japan.
JAMA network open
|January 20, 2026
概括
年龄较大的母亲的孩子患食物过敏,喘息和家庭灰尘虫敏感性的风险较低. 晚年母亲的年龄可能会对早期儿童的过敏性疾病提供保护.
科学领域:
- 环境健康 环境健康
- 儿科过敏 儿科过敏
- 生殖流行病学 生殖流行病学
背景情况:
- 儿童过敏疾病源于复杂的基因环境相互作用.
- 高龄的父母与遗传和表观遗传变化有关,但其对儿童过敏风险的影响尚不清楚.
研究的目的:
- 调查父母在分娩时的年龄与儿童早期过敏性疾病的风险之间的联系.
主要方法:
- 一项全国范围的前性出生队列研究 (日本环境和儿童研究) 包括34942对母婴.
- 医生诊断的过敏结果 (食物过敏,喘息,喘,湿疹) 和家庭灰尘虫 (HDM) 敏感性被评估到4岁.
- 用多变量逻辑回归与多次归算来计算调整的赔率比率 (ORs).
主要成果:
- 与25-29岁的母亲相比,35-39岁 (OR,0.79) 和40岁以上 (OR,0.59) 的母亲的孩子在1岁时患食物过敏的几率较低.
- 35岁以上父母的孩子在4岁时喘息的几率较低 (OR,0.89).
- 年龄较大的母亲的孩子显示HDM敏感性的几率降低 (例如,母亲35-39:OR,0.68).
结论:
- 先进的孕产妇年龄与儿童早期食物过敏,喘息和HDM敏感性的几率降低有关.
- 这些发现表明,晚年母亲的年龄对儿童发展过敏疾病有潜在的保护作用.
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