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在美国进行五年绝对基于风险和基于年龄的乳腺癌查
Oguzhan Alagoz1, Yifan Lu1, Eugenio Gil Quessep2
1Department of Industrial and Systems Engineering, University of Wisconsin-Madison.
基于风险的乳房造影查可以避免与基于年龄的查相似的或更多的乳腺癌死亡,同时减少假阳性. 这种个性化的方法为预防乳腺癌提供了更为定制的策略.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 预防医学 预防医学
- 生物统计学 生物统计学
背景情况:
- 目前的乳房造影查指南是基于年龄的,不考虑个体乳腺癌风险.
- 个性化,基于风险的方法可以优化查的有效性,减少不必要的召回.
研究的目的:
- 为了比较基于风险的乳房扫描查策略与传统基于年龄的策略的有效性.
- 为了评估对乳腺癌死亡率和假阳性查的影响,召回.
主要方法:
- 一个使用两种癌症干预和监测建模网络 (CISNET) 乳腺癌模型的决策分析模型.
- 模拟40岁以上没有乳腺癌病史的美国女性,使用数字乳腺图莫合成.
- 对比了47个基于风险的策略和3个基于年龄的策略与没有查的场景.
主要成果:
- 与两年一次的基于年龄的查 (年龄40-74岁) 相比,九种基于风险的策略避免了同样多或更多的乳腺癌死亡.
- 与以年龄为基础的查相比,基于风险的策略将假阳性召回率降低了8%-23% .
- 一个特定的基于风险的策略表明,避免的死亡人数增加了6%,假阳性病例减少了13%.
结论:
- 基于人群风险的乳房扫描查提供了与基于年龄的查相匹配或优越的好处.
- 基于风险的查显著减少了假阳性召回,提高了患者的护理.
- 个性化,基于风险的查是未来乳腺癌预防策略的一个有希望的基石.
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