免疫路径和产前/产周环境暴露有助于表观遗传妊娠年龄预测和加速
Amy A Eapen1,2, Ian M Loveless3,4, Mingming Pan3,4
1Division of Allergy and Immunology, Department of Internal Medicine, Henry Ford Health + Michigan State University Health Sciences, Detroit, MI, USA.
Epigenetics
|January 20, 2026
概括
DNA甲基化分析揭示了与妊娠年龄 (GA) 和表观遗传年龄加速 (EGAA) 相关的关键部位. 这项研究使用了喘和过敏阵列,并确定了与GA和影响EGAA的出生顺序相关的T细胞路径.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 免疫学 免疫学 免疫学
背景情况:
- 基因甲基化 (DNAm) 反映了由环境因素影响的慢性妊娠年龄 (GA) 和表观遗传妊娠年龄加速 (EGAA).
- 喘和过敏DNAm阵列针对喘和过敏位点,但其与GA和EGAA的关联,特别是关于产前暴露,尚未评估.
- 了解这些关联对于识别早期对发展和健康结果的环境影响至关重要.
研究的目的:
- 评估喘和过敏阵列上的DNAm位点与新生儿的时间 GA 和 EGAA 的关联.
- 开发和验证用于预测GA的多CpG甲基化模型.
- 评估产前/产周环境因素对GA,表观遗传妊娠年龄 (EGA) 和EGAA的影响.
主要方法:
- 在391名新生儿的带血DNAm上进行了全表观基因组关联研究 (EWAS),以确定与慢性GA相关的CpG位点.
- 开发了一个多CpG位点甲基化模型来预测GA.
- 使用多次暴露模型分析了产前/产周因素与GA,EGA和EGAA之间的关联.
主要成果:
- 确定了2435个与慢性GA相关的CpG位点,特别是在HLAII类位点内.
- 开发的多CpG模型实现了高预测准确度 (R2 = 0.88) 的GA.
- 基于区域的分析显示了与GA相关的T助手1/2激活,B细胞发育和IL-10信号通路的丰富.
- 在多次暴露模型中,婴儿的长子身份和母亲的平价与EGAA有显著的关联.
结论:
- 慢性GA与T细胞调节的途径和抗原呈现过程有关.
- 产前和产周因素,如出生顺序和母体平价,可能会影响表观遗传妊娠年龄加速.
- 喘和过敏阵列的内容显示了GA和EGAA的相关性,提供了对早期生活环境对发展的影响的见解.
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