用化疗和布林托马布治疗的婴儿急性白血病的成功长期缓解:一个病例报告
Qiuying He1, Bin Zhang1, Shuang Li1
1Department of Pediatric Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
The American journal of case reports
|January 20, 2026
概括
布利纳图莫马布为婴儿B细胞急性淋巴细胞白血病 (B-ALL) 提供了一个有前途的治疗方法. 这种向治疗,结合化疗,在婴儿患者中实现了长期存活,并具有可控的副作用.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 布利纳图莫马布是针对复发性/耐药性B细胞急性淋巴细胞白血病 (B-ALL) 的向疗法.
- 关于在诊断后婴儿使用布利纳图马布的数据有限.
- 婴儿B-ALL治疗传统上存在严重不良反应的风险.
研究的目的:
- 报告一个婴儿B-ALL.成功治疗布利纳图马布的病例.
- 为了评估blinatumomab在这个儿科群体中的安全性和有效性.
- 为突出blinatumomab作为婴儿白血病的潜在治疗选择.
主要方法:
- 一个婴儿被诊断患有B-ALL的病例报告.
- 治疗涉及布利纳图马布和化疗的组合.
- 在治疗期间监测疗效和不良反应.
主要成果:
- 婴儿实现了长期生存和疾病缓解.
- 患者耐受了布利纳图马布治疗方案,并有可控的不良事件 (发烧,感染,过氨基酶水平升高).
- 在这个婴儿中,BLINATUMOMAB表现出了有利的安全性.
结论:
- 布莱纳托马布显示,作为婴儿B-ALL.安全有效的治疗方法具有前途.
- 在诱导期间服用布利纳图马布可能会改善缓解率并减少药物不良反应.
- 与低强度化疗联合治疗可能会维持长期缓解.
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