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饮食和尿液中的与甲状腺癌风险有关:一个元分析
Cancer control : journal of the Moffitt Cancer Center
|January 20, 2026
概括
高尿水平与甲状腺癌 (TC) 的风险增加有关,包括乳头甲状腺癌 (PTC) 和乳头甲状腺微癌 (PTMC). 然而,饮食中的摄入量在此元分析中没有显示出与TC风险的显著关联.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 摄入量与甲状腺癌风险之间的关系,特别是乳头甲状腺癌 (PTC),是复杂的和争论的.
- 了解这种关联对于公共卫生和甲状腺疾病的临床管理至关重要.
研究的目的:
- 进行一项元分析,评估摄入量与甲状腺癌 (TC) 发病率之间的风险关联.
- 具体评估与暴露有关的乳头甲状腺癌 (PTC) 和乳头甲状腺微癌 (PTMC) 的风险.
主要方法:
- 在四个主要数据库 (Cochrane Library,Embase,PubMed,Web of Science) 系统搜索相关研究.
- 包括17项研究,共有273,651名参与者,使用纽卡斯尔-太华尺度评估质量.
- 使用Stata 17进行的统计分析,以确定赔率比率和置信区间.
主要成果:
- 高尿的度与TC的风险增加显著相关 (OR:6.43,P <.05).
- 观察到乳头甲状腺癌 (PTC) (OR:7.56,P <.001) 和乳头甲状腺小癌 (PTMC) (OR:8.96,P <.001) 的风险增加.
- 在饮食中摄入量和TC风险之间没有发现显著的关联 (OR:0.75,P > .05).
结论:
- 高尿分泌量绝对与甲状腺癌的风险增加有关.
- 饮食中摄入量与TC风险之间的关联需要进一步研究.
- 未来需要大规模的前性研究来验证这些发现,并澄清饮食中的作用.
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