Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.6K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

4.0K
4.0K
Global Regulatory Systems01:28

Global Regulatory Systems

623
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
623
Sanger Sequencing01:57

Sanger Sequencing

773.5K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
773.5K
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

503
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...
503
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.4K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

PEPE: scalable extraction of multi-modal protein language model representations.

Bioinformatics (Oxford, England)·2026
Same author

Transient SUMOylation inhibition in human pre-adipocytes stably imprints a transcriptional beiging fate.

Nucleic acids research·2026
Same author

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood.

Science advances·2026
Same author

Correction: B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2.

The Journal of experimental medicine·2026
Same author

Intraluminal Gastric Band Migration Causing Small Bowel Occlusion.

Annali italiani di chirurgia·2026
Same author

Spike Train Scalograms (STS): a Deep Learning Classification Pipeline for Neuronal Cell Types.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025

相关实验视频

Updated: Jan 22, 2026

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

10.8K

inMOTIFin:用于监管序列的轻量级端到端模拟软件.

Katalin Ferenc1, Lorenzo Martini1,2, Ieva Rauluseviciute1

  • 1Norwegian Centre for Molecular Biosciences and Medicine (NCMBM), Nordic EMBL Partnership, University of Oslo, Oslo 0318, Norway.

Bioinformatics (Oxford, England)
|January 20, 2026
PubMed
概括

inMOTIFin是一个新的Python软件,用于模拟和修改DNA调节序列. 它有助于开发和评估用于转录监管语法分析的生物信息学工具.

关键词:
基因调节 基因调节 基因调节监管语法 监管语法 的语法模拟模拟是指一个模拟模拟.转录因子是一种转录因子.

更多相关视频

Discovering CsgD Regulatory Targets in Salmonella Biofilm Using Chromatin Immunoprecipitation and High-Throughput Sequencing ChIP-seq
13:48

Discovering CsgD Regulatory Targets in Salmonella Biofilm Using Chromatin Immunoprecipitation and High-Throughput Sequencing ChIP-seq

Published on: January 18, 2020

8.0K
Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

7.1K

相关实验视频

Last Updated: Jan 22, 2026

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

10.8K
Discovering CsgD Regulatory Targets in Salmonella Biofilm Using Chromatin Immunoprecipitation and High-Throughput Sequencing ChIP-seq
13:48

Discovering CsgD Regulatory Targets in Salmonella Biofilm Using Chromatin Immunoprecipitation and High-Throughput Sequencing ChIP-seq

Published on: January 18, 2020

8.0K
Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

7.1K

科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 对转录性调节语法的准确分析需要对方法验证进行受控模拟.
  • 现有的模拟工具往往缺乏灵活性和整合方便性,阻碍了实际应用.

研究的目的:

  • 介绍inMOTIFin,一个用户友好的Python软件,用于模拟和修改DNA调节序列.
  • 为开发和评估生物信息学框架提供多功能和高效的工具,用于转录性监管语法分析.

主要方法:

  • inMOTIFin提供了调节序列的模块化和灵活的模拟.
  • 它允许可定制的图案生成,精确控制图案实例 (位置,并发,间距),并直接修改真实序列.
  • 该软件以Python实现,可通过PyPI和Docker Hub获得.

主要成果:

  • inMOTIFin有助于创建可控数据集,用于评估动机发现算法.
  • 它支持对转录因子合作性的分析,并有助于解释基因调节的深度学习模型.
  • 该软件可确保对转录性调节语法进行可靠和可重复的分析.

结论:

  • inMOTIFin解决了现有模拟器的局限性,提供了更高的灵活性和易用性.
  • 它是用于转录监管语法生物信息学框架的准确开发,评估和解释的宝贵工具.
  • 该软件促进了该领域的强大和可重复的研究.