疫苗表达系统和孕产妇/新生儿因素:对早产婴儿B型肝炎免疫疗效的影响
Lu Shen1, Yan Xie1, Zhongkui Zhu1
1Department of Expanded Programme on Immunization, Taizhou City Center for Disease Control and Prevention, Taizhou, Jiangsu, China.
Human vaccines & immunotherapeutics
|January 20, 2026
概括
乙型肝炎疫苗在早产婴儿中非常有效,达到99.43%的血清保护. 诸如妊娠年龄和疫苗接种时间表等因素会影响抗体水平,指导未来的婴儿免疫策略.
科学领域:
- 新生儿免疫学 新生儿免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 全球早产率的增加需要有效的乙型肝炎预防策略.
- 建议早产婴儿接种乙型肝炎疫苗,但免疫性需要进一步研究.
研究的目的:
- 评估B型肝炎疫苗在早产婴儿中的免疫性.
- 确定影响抗体反应的因素,包括妊娠年龄和免疫接种方案.
主要方法:
- 对完成乙型肝炎疫苗系列的699名早产婴儿的分析.
- 使用几何平均度 (GMC) 和血清保护率 (SPR) 评估免疫性.
主要成果:
- 高整体血清保护率 (99.43%) 和几何平均度 (986.36 mIU/mL).
- 妊娠年龄小于28周的婴儿显示更高的GMC (3,735.59 mIU/mL).
- 与混合计划 (691.91 mIU/mL) 相比,统一的疫苗计划导致更高的GMC (1,281.26 mIU/mL).
结论:
- 乙型肝炎疫苗在早产婴儿中诱导强烈的免疫反应.
- 抗体反应大小的变化可能与疫苗表达系统有关.
- 这些发现可以为早产人口提供优化疫苗接种策略的信息.
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