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Updated: Jan 22, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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在Paenibacillus中通过化学生物合成途径多样化三素化学空间

Nataliia V Machushynets1, Barbara R Terlouw2, Le Zhang1

  • 1Molecular Biotechnology Group, Institute of Biology, Leiden University, Sylviusweg 72, Leiden 2333 BE, The Netherlands.

Journal of natural products
|January 20, 2026
PubMed
概括

化学生物合成使Paenibacillus细菌能够产生多种类型的tridecaptin脂抗生素. 这种策略产生了像Oct-TriA5这样的新型化合物,具有针对具有挑战性的病原体的广泛活性.

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