产前暴露于野火和儿童自闭症
David G Luglio1, Xin Yu2, Jane C Lin3
1Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70118, United States.
Environmental science & technology
|January 20, 2026
概括
产前暴露于野火烟雾,特别是细颗粒物 (PM2.5),可能会增加儿童自闭症的风险. 在第三季度增加野火烟雾暴露日数与更高的自闭症诊断有关.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 流行病学 流行病学
背景情况:
- 野火细颗粒物 (PM2.5) 对神经发育的慢性健康影响在很大程度上是未知的.
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,具有潜在的环境风险因素.
研究的目的:
- 评估南加利福尼亚州怀孕队列中产前暴露于野火PM2.5和自闭症诊断之间的关联.
- 调查特定的暴露指标,包括度,暴露日数和烟雾波.
主要方法:
- 在怀孕队列 (2006-2014) 中使用了考克斯的比例危险模型,在5岁时有3356例自闭症诊断.
- 使用三个野火PM2.5指标估计的暴露:平均度,烟雾暴露日数和烟雾暴露波数.
- 对不移动的孕妇进行了敏感性分析,并仅限于PM2.5度值 (3和5μg/m3) 的分析.
主要成果:
- 自闭症风险增加与第三个三个月内接触野火的日数较多有关.
- 对于不移动的人来说,这种关联是最强的,暴露时间>10天的危险比率 (HR) 高达1.225日.
- 风险在第三季度每次野火波暴露增加 (所有人的HR为1.073,非移动者的HR为1.267).
- 没有发现与单独平均野火PM2.5度的相关性.
结论:
- 产前暴露在野火烟雾中,特别是在第三个三个月,可能会增加儿童患自闭症的风险.
- 与烟雾存在 (天,波) 相关的暴露指标与自闭症风险的关联比平均度更强.
- 需要进一步的研究来阐明将野火烟雾暴露与神经发育结果联系在一起的机制.
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