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Updated: Jan 22, 2026

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对于未知的原发性HPV相关状细胞癌的冷切口的准确性
Sindhura Sridhar1, Annie Moroco2, Shravan Gowrishankar1
1Vanderbilt University Medical Center, Department of Otolaryngology - Head and Neck Surgery, 1215 21(st) Ave. S., Nashville, TN 37232, United States.
Oral oncology
|January 20, 2026
概括
冷截面分析 (FSA) 对于识别未知原发性转移性状细胞癌 (SCCUP) 中的原发性瘤非常有价值,在本研究中显示了超过85%的灵敏度和负预测值.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 头部和部手术 头部和部手术
- 在瘤学瘤学.
背景情况:
- 未知原发性转移性状细胞癌 (SCCUP) 管理指南建议对可疑的原发性部位进行冷截面分析 (FSA).
- 这项研究评估了FSA在识别HPV相关SCCUP的诊断准确性.
研究的目的:
- 评估冷截面分析 (FSA) 的诊断准确性,以确定未知原发性皮细胞癌 (SCCUP) 患者的原发性瘤.
- 在这个患者队列中确定FSA的灵敏度,特异性,正预测值 (PPV) 和负预测值 (NPV).
主要方法:
- 77名活检证明p16阳性SCCUP患者的回顾性队列研究.
- 在诊断操作期间进行的FSA的诊断准确度 (灵敏度,特异性,PPV,NPV) 的分析.
- 包括接受过口腔横向机器人手术 (TORS) 或直接喉腔镜和活检的患者.
主要成果:
- 在82%的患者中发现了原发性瘤.
- 冷截面分析 (FSA) 显示SCCUP的灵敏度为86%,特异性为100%,PPV为100%,NPV为86%.
- 与TORS切割样本相比,直接喉腔镜活检的灵敏度 (100%) 和NPV (100%) 较高 (77%的灵敏度和NPV).
结论:
- 冷截面分析 (FSA) 是用于诊断未知初级状细胞癌 (SCCUP) 的诊断手术的宝贵工具.
- 该研究证实了FSA在SCCUP病例中识别原发性瘤时的高灵敏度和负预测值.
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