在澳大利亚的背景下,通常隔离的无氧细菌的体外抗微生物敏感性趋势在澳大利亚的背景下
Victoria Jordan1, Hemalatha Varadhan1
1NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
Diagnostic microbiology and infectious disease
|January 20, 2026
概括
在厌氧细菌中观察到对常见的抗生素,如阿莫西西林克拉夫兰酸和克林达米辛的高耐药性,包括Prevotella spp. 和Clostridium perfringens. 这是一个非常好的例子. 这表明,在某些临床情况下,可能需要对无氧生物进行常规抗生素敏感性测试.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 对无氧细菌的抗生素敏感性测试不是经常进行的.
- 通常使用无氧覆盖的经验性抗生素.
- 对抗厌氧剂的新兴耐药性需要重新评估当前的做法.
研究的目的:
- 为了确定经常隔离的无氧细菌的表型抗微生物敏感性概况.
- 评估关键无氧病原体的耐药性模式.
主要方法:
- 使用EUCAST方法对Prevotella spp.,Clostridium perfringens和Cutibacterium acnes进行敏感性测试.
- 使用Thermo Fisher Anaerobe Sensititre板测试阳性无氧 (GPAC) 的测试.
- 包括Fenegoldia magna,Parvimonas micra和Peptoniphilus spp. 在其中. 在GPAC测试中.
主要成果:
- 在Prevotella spp.中对阿莫西西林-克拉夫兰酸盐和克林达米辛的高耐药率 (53.3%和50%).
- 在Clostridium perfringens中观察到43.3%的克林达米辛耐药性.
- 显著的克林达米辛和四环素耐药性,在格拉姆阳性无氧菌中发现.
结论:
- 在Prevotella spp.中存在高耐药率. 几种物种中克林达米辛的存在,需要考虑无氧敏感性测试.
- 实验室应考虑在特定情况下进行敏感性测试,特别是对于与Prevotella相关的感染或当克林达米辛是主要治疗时.
- 甲尼达在所有测试生物体中都表现出持续的敏感性.
关键词:
无氧敏感性测试试验 无氧敏感性测试克洛斯特里 (Clostridium perfringensens) 是一种有毒的植物.这种细菌是Cutibacterium acnes.这种细菌名为Fusobacterium necrophorum.格拉姆阳性无氧菌.普雷沃特拉 (Prevotella) 在投票中表示支持.更多相关视频
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