不平等的负担:内腔哨兵淋巴结活检和黑色素瘤感染的不成比例的风险
Aleksandra Nowak1, Jessica Coyle1, Abigail Colletta1
1St George's Hospital, Blackshaw Rd, London SW17 0QT, United Kingdom.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
|January 20, 2026
概括
针对黑色素瘤的哨戒淋巴结活检 (SLNB) 后的手术部位感染率受到解剖部位的显著影响,手指手术具有最高风险. 男性性别也独立地预测了这个英国队列中感染风险的增加.
科学领域:
- 黑色素瘤治疗方法
- 手术瘤学手术瘤学
- 传染病流行病学 传染病流行病学
背景情况:
- 哨兵淋巴结活检 (SLNB) 是黑色素瘤的关键分期程序.
- 了解SLNB后的手术部位感染 (SSI) 率对于患者的治疗结果和医疗保健资源管理至关重要.
- 根据解剖部位和患者人口统计数据,SSI率的变化需要进行调查.
研究的目的:
- 为了评估瘤的哨戒淋巴结活检 (SLNB) 后的手术部位特定感染率.
- 确定SLNB后手术后感染的独立预测因子.
主要方法:
- 对从422名接受SLNB治疗的患者前性收集的数据进行了回顾性分析.
- 包括人口统计数据,SLNB位置和结果,并发病症和抗生素预防的数据.
- 多变量逻辑回归分析以确定感染预测因素,遵守STROBE指南.
主要成果:
- 在422名患者中,总体感染率为13% (55例).
- 根据SLNB部位感染率的显著变化: inguinal (23.9%),膝盖 (29.4%),部 (7.8%),和头部/部 (3.0%).
- 阴道部位 (OR 5.01) 和男性性别 (OR 2.57) 是术后感染的独立预测因素;年龄和并发症不显著.
结论:
- SLNB的解剖位置是术后感染风险的首要决定因素, inguinal手术的风险最高.
- 男性患者在SLNB后显示出具有统计学意义的感染风险增加.
- 这些发现支持实施有针对性的预防策略,并加强对高风险患者群体和手术场所的监测.
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