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Updated: Jan 22, 2026

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大脑血动力学和白质超强度:使用非侵入性脑成像的研究结果
Ashwati Vipin1, James Xiao Yuan Chen1, Mervin Tee2
1Dementia Research Centre (Singapore), 11 Mandalay Road, Lee Kong Chian School of Medicine, Nanyang Technology University, 308232, Singapore.
The journal of prevention of Alzheimer's disease
|January 20, 2026
概括
大脑血流和动脉过渡时间影响血脑屏障的透性,这影响小血管疾病中的白质超强度负担. 血管风险因素也会影响这些神经血管措施.
科学领域:
- 神经成像是一种神经成像.
- 血管神经学 血管神经学
- 老年学是一门学科.
背景情况:
- 在小血管疾病 (SVD) 中,用于表征血脑屏障 (BBB) 变化和 perfusion 缺陷的非侵入性神经成像尚未得到充分研究.
- 白质过强度 (WMH) 是SVD的一个关键特征,与认知衰退和衰老有关.
研究的目的:
- 通过检查脑血流 (CBF),BBB透性和WMH负担之间的关系来研究WMH的血液动力学基础.
- 探索血管风险因素对这些神经血管参数的影响.
主要方法:
- 来自新加坡生物标志物和认知队列研究的128名参与者的横截面研究.
- 使用多回声动脉旋转标记 (ASL) 来得出CBF,动脉过渡时间 (ATT) 和BBB交换时间 (Tex).
- 采用结构方程建模来分析神经血管测量和WMH之间的复杂相互作用.
主要成果:
- 较低的CBF,较长的ATT和较短的BBBTex独立地与更高的WMH负担和更高的年龄有关.
- CBF和ATT预测了BBB透性,这反过来预测了更高的WMH负担.
- 诸如高血压和高HbA1c等血管风险因素与降低CBF和改变BBB Tex有关.
结论:
- CBF和ATT是BBB透性的关键决定因素,影响SVD中的WMH负担.
- 血管风险因素显著影响神经血管测量,突出显示它们在SVD病变发生过程中的作用.
- 研究结果支持BBB完整性和 perfusion deficits 在SVD中的关键作用.
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