孕期暴露于金属和小脆弱的新生儿:一个系统的审查和元分析
Guoqi Yu1, Xi Meng2, Yue Qian Tan3
1Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, 117549, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, 119228, Singapore; Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, 117456, Singapore; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.
孕期接触,和等重金属与早产,低出生体重和新生儿怀孕年龄较小的风险增加有关. 这些发现凸显了怀孕期间环境监测的必要性.
科学领域:
- 环境健康 环境健康
- 围产期流行病学 围产期流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 小脆弱新生儿 (SVNs) 面临慢性疾病和死亡率的风险增加.
- 孕期接触重金属是SVN发展的潜在因素.
- 之前对单个金属和SVN结果的审查是有限的和不确定的.
研究的目的:
- 综合综合综合证据关于多重金属暴露和SVN结果之间的关联.
- 评估各种生物标本的发现,并更新现有知识.
- 提供对重金属对新生儿健康影响的完整评估.
主要方法:
- 在PubMed,Web of Science和Embase数据库中进行了系统的搜索.
- 包括观察性研究 (队列,病例控制,横截面),分析生物监测数据.
- 进行了元分析,计算了合并的几率比率,并进行了剂量反应分析.
主要成果:
- 102项涉及325,705名分娩的研究将20种重金属与SVN结局联系起来.
- ,和暴露与早产风险增加,出生体重低,妊娠年龄相对小的风险显著相关.
- 特定的金属生物样品组合显示出与SVN风险的明显关联.
结论:
- 孕期暴露于各种金属化物与SVN的风险增加有显著的联系.
- 这些暴露可能会对儿童产生终身健康影响.
- 在怀孕期间对环境有毒金属暴露的监管对于减轻不良出生结果至关重要.
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