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在小鼠中,吸入六价暴露会诱导潜在的肺损伤和部分内源性修复的代谢重编程
Changmao Long1, Yuexuan Wang2, Yeting Peng2
1School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, PR China; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
Ecotoxicology and environmental safety
|January 20, 2026
概括
六价暴露会导致肺损伤和全身积累. 代谢学揭示了改变的脂质和pyrimidine通路,有潜在的生物标志物用于监测和治疗.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢学 代谢学 代谢学
背景情况:
- 六价[Cr(VI) 是一个重要的职业和环境呼吸道毒素.
- 肺毒性和Cr (VI) 暴露的修复机制尚未完全理解.
研究的目的:
- 为了研究Cr (VI) 吸入对小鼠肺部的代谢作用.
- 为了确定Cr (VI) 暴露和肺损伤的生物标志物.
主要方法:
- 小鼠通过吸入气溶中的Cr(VI) 暴露了28天,随后恢复了2周.
- 评估了肺功能,支气管洗液 (BALF) 炎症细胞,组织病理学,并进行了非向的肺代谢.
- 使用感应合等离子体质谱法量化血液水平.
主要成果:
- 吸入Cr (VI) 导致全身积累,肺炎,厚化和肺功能受损.
- 代谢分析显示,阿拉基酸,酸和金胺路径的显著变化.
- 主要代谢物如前列腺素E2,12-Hydroxyheptadecatrienoic acid (12S-HHT),cytidine和uridine的含量都增加了.
- 恢复阶段出现了改善,葡萄糖脂和阿拉基酸代谢与修复过程有关.
- 12S-HHT和类胆与负担和肺功能下降相关.
结论:
- 吸入Cr (VI) 会导致严重的肺损伤和代谢障碍,特别是在脂质代谢中.
- 参与酸和葡萄糖脂通路的代谢物对Cr (VI) 毒性和肺部修复至关重要.
- 已识别的代谢物作为CrVI暴露和肺损伤的潜在生物标志物,有助于生物监测和治疗策略.
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