跨采矿地点的可呼吸矿物灰尘毒性:在地下矿山中对现场样本进行比较研究
Yi-Hsuan Chen1, Matthew Gibb2, Stephen Brindley3
1Department of Environmental Health Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
The Science of the total environment
|January 20, 2026
概括
现代煤炭开采产生细微的可呼吸颗粒,对健康构成风险. 颗粒大小和元素组成显著影响毒性,导致地下矿工的细胞损伤和炎症.
科学领域:
- 职业健康 职业健康 职业健康
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
背景情况:
- 现代的煤炭开采机械产生细微的空气颗粒.
- 这些细颗粒给地下矿工带来了严重的健康问题.
研究的目的:
- 为了研究颗粒大小对地下矿山尘埃毒性的影响.
- 在人类细胞模型中识别导致尘埃毒性的因素.
主要方法:
- 从美国各个地下煤矿地点收集了尘埃样本.
- 使用DLS,T/SEM和STEM-EDX分析了粒子大小,形态和元素组成.
- 通过ICP-MS.评估人类THP-1细胞毒性 (活力,线粒体应激,炎症) 和量化颗粒吸收.
主要成果:
- 在所有尘埃样本中检测到可呼吸颗粒 (低至500nm).
- 观察到尺寸依赖的粒子吸收和多样化的元素组成.
- 暴露后证明了细胞活力的剂量依赖性下降和炎症标志物的增加.
结论:
- 煤矿中可呼吸颗粒的毒性受到大小和元素组成的影响.
- 颗粒的特性和金属含量是细胞吸收,代谢破坏和炎症的关键驱动因素.
- 健康风险评估至关重要,特别是在高暴露区域,如煤运输输送带.
相关概念视频
Water and Mineral Acquisition
35.4K
Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
35.4K
Design Example: Identifying the Locations of Monuments in the Field Using Global Positioning System Device
387
Surveyors use Global Positioning System (GPS) technology to measure the precise location and elevation of points on Earth. In a recent survey, GPS receivers were used to determine the coordinates and elevations of two park monuments. The process involved careful mission planning, data collection, and correction to ensure accuracy. The survey began with mission planning to identify optimal satellite visibility and minimize Position Dilution of Precision (PDOP). A geodetic control point...
387
Respiration
4.1K
Overview of the Respiratory System and Energy Production
Energy production in the human body is primarily fueled by oxidation, a process where food molecules are burned by combining with oxygen to produce carbon dioxide and water. This vital metabolic process sustains life, and is supported intricately by the respiratory system.
Structure and Function of the Respiratory System:
The respiratory system is a complex network of structures that includes the nose, oropharynx, larynx, trachea,...
Energy production in the human body is primarily fueled by oxidation, a process where food molecules are burned by combining with oxygen to produce carbon dioxide and water. This vital metabolic process sustains life, and is supported intricately by the respiratory system.
Structure and Function of the Respiratory System:
The respiratory system is a complex network of structures that includes the nose, oropharynx, larynx, trachea,...
4.1K
Minerals
1.1K
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Major...
Major...
1.1K
Physiology of Respiration II: Neurogenic Control of Respiration
1.9K
The neurogenic control of respiration coordinates various neural networks and pathways to regulate breathing rate and depth, meeting the body's oxygen and carbon dioxide exchange requirements. This system adapts to physiological and environmental conditions, ensuring optimal breathing patterns.
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
Central Control
The brainstem is the primary site of central control, hosting respiratory centers:
1.9K
Respiration Pathways
721
Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
721


