揭示睡眠特征与生殖癌症之间的关联:系统性审查和元分析
Eirini Pagkalidou1, Christos K Papagiannopoulos1, Maria Manou1
1Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece.
Sleep medicine reviews
|January 20, 2026
概括
晚间时间型和失眠与增加生殖癌症风险有关. 循环节障碍可能在癌症的发展中发挥作用,这突出了对预防癌症的睡眠行为修改研究的需要.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠特征是可修改的生活方式因素,可能对癌症风险产生影响.
- 睡眠特征与生殖癌症之间的关联需要进一步研究.
研究的目的:
- 系统地审查和对睡眠特征和生殖癌症之间的关联进行观测研究进行元分析.
- 探索时间型和失眠对乳腺,前列腺,子宫内膜和上皮卵巢癌风险的影响.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行系统的文献搜索 (直到2024年9月).
- 包括62项观察性研究 (45个队列,17个病例控制) 用于元分析.
- 随机效应和剂量反应元分析是在从最大调整模型中提取的数据上进行的.
主要成果:
- 晚间时间型与患乳腺癌 (HR=1.12) 和上皮卵巢癌 (HR=1.15) 的风险更高有关.
- 失眠与乳腺癌风险增加有关 (RR=1.23),尽管异质性很高,在严格调整的研究中,这种关联减少了.
- 在失眠和乳腺癌相关性方面发现了显著的异质性,需要谨慎解释.
结论:
- 研究结果表明,昼夜干扰在致癌过程中起着作用,特别是在生殖癌症方面.
- 建议使用客观睡眠指标进行进一步的研究.
- 研究修改睡眠行为和昼夜调整以减少癌症风险的潜力是有必要的.
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