在儿科功能神经障碍中,症状是否被分为潜在类别?
Akihiro Nishi1, Itaru Hayakawa2, Yusuke Okubo3
1Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA; California Center for Population Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Epilepsy & behavior : E&B
|January 20, 2026
概括
澳大利亚的儿科功能神经障碍 (FND) 症状最好通过两个不同的子组来解释,而不是一个. 这些组,功能分离性发作 (FDS) 和功能运动障碍 (FMD),表现出症状重叠但不同的模式.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 儿科 儿科 儿科
背景情况:
- 功能神经障碍 (FND) 包括功能/离散性 (FDS) 和功能运动障碍 (FMD).
- FND内部的异质性表明FDS和FMD可能是不同的实体.
- 了解FND亚型对于准确的诊断和治疗至关重要.
研究的目的:
- 为了确定儿科FND症状是否最好由单个疾病实体或多个不同的实体来解释.
- 为了研究澳大利亚儿科FND患者队列中的症状变异.
主要方法:
- 隐性类分析 (LCA) 用于确定155名儿科FND患者中的子组.
- 数据包括四个类别的症状存在/不存在:负运动,积极运动,感官缺陷和功能性.
- 根据非随机的症状并发模式,LCA确定了潜在类别.
主要成果:
- 一个两种类型的模型提供了一个比单,三或四种类型的模型更好的合适 (BIC: 839.2).
- 第1类 (70.7%) 呈现频繁的负和正运动症状,偶尔出现FDS和感官缺陷.
- 2类 (29.3%) 主要表现为FDS (100%),偶尔有感官缺陷和积极的运动症状,以及罕见的负面运动症状.
结论:
- 澳大利亚儿科FND队列最好用一个两类模型来表示.
- 这两个类别表现出显著的症状重叠,但不同的潜在模式.
- 这一发现支持在更广泛的FND类别中对FDS和FMD的潜在区分.
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