TE和TR对明显扩散系数和扩散衍生的血管密度量化的影响:对健康肝脏和脏的研究
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
概括
在MRI中优化回声时间 (TE) 和重复时间 (TR) 显著影响肝脏和脏的明显扩散系数 (ADC) 和扩散衍生的血管密度 (DDVD) 值,可能提高病变检测.
科学领域:
- 磁共振成像 (MRI) 是一种磁共振成像技术.
- 扩散权重成像 (DWI) 是一种扩散权重成像技术.
- 腹部成像 腹部成像 腹部成像
背景情况:
- 肝脏和脏表现出明显的T1和T2放松特性.
- 的T2放松时间与肝细胞癌的时间相当.
- 扩散MRI参数对序列时间变化敏感.
研究的目的:
- 为了研究回声时间 (TE) 和重复时间 (TR) 对明显扩散系数 (ADC) 和扩散衍生的血管密度 (DDVD) 在健康的肝脏和脏的影响.
- 评估TE和TR的变化如何影响脏和肝脏之间的ADC和DDVD的比率.
- 确定优化TE和TR的潜力,以改善腹部扩散MRI中的病变检测能力和对比度.
主要方法:
- 在6名健康志愿者身上进行了扩散核磁共振扫描,时间为3.0T.
- TE是不同的 (46-80毫秒),而TR是固定在2000毫秒.
- TR是变化的 (200-2000 ms),而 TE是固定在46 ms.
- 使用0和600秒/mm2的b值计算ADC.
- 使用b=0和非常低的b值 (1-10秒/毫米2) 之间的信号差异来计算DDVD.
主要成果:
- 增加TE导致肝脏和脏的ADC值增加,但ADC比率 (脏/肝脏) 降低.
- 增加TR导致两个器官的ADC值下降,ADC比率 (脏/肝脏) 也下降.
- 增加TE降低了DDVD值,并增加了DDVD比率 (脏/肝脏).
- 增加TR显示了DDVD的两相变化,TR=500毫秒的峰值值,DDVD比率 (脏/肝脏) 的单相下降.
结论:
- TE和TR显著影响肝脏和脏中的ADC和DDVD量化.
- 增加TE或TR会降低ADC比率 (/肝).
- 较长的TE增加了DDVD比率 (脏/肝脏).
- 优化TE和TR可能会提高ADC和DDVD地图上的病变检测和对比度.
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