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在糖尿病足综合征中,截肢风险与营养状况之间是否存在关联?
Erdi Imre1, Sadettin Öztürk2, Eren İmre3
1Orthopaedics and Traumatology, Istanbul Bakirkoy Dr Sadi Konuk Training and Research Hospital, Bakırköy/İstanbul, Turkey.
Zeitschrift fur Orthopadie und Unfallchirurgie
|January 20, 2026
概括
糖尿病足综合征 (DFS) 患者的高CONUT分数 (≥5) 面临2.28倍的下肢截肢的风险增加. 这突显了CONUT得分作为DFS中截肢的关键预测指标.
科学领域:
- 内分泌学和新陈代谢学
- 血管外科 血管外科
- 营养科学 营养科学
背景情况:
- 糖尿病足综合征 (DFS) 影响15-25%的糖尿病患者,需要确定营养不良的危险因素.
- 早期识别和预防策略对于管理DFS和预防截肢等严重结果至关重要.
研究的目的:
- 为了研究简单的血液参数,营养指数和糖尿病脚截肢之间的关联.
- 为了确定通过特定的血液标志物评估的营养状况是否预测了DFS患者的截肢风险.
主要方法:
- 一个单中心,横截面的观察性研究包括237名DFS患者 (≥18岁) 诊断为DFD.
- 患者被分为截肢 (A组,n=92) 和非截肢 (NA组,n=145) 组.
- 统计分析比较了各组之间的血液参数和营养指数 (CRP/白蛋白比,白蛋白/球蛋白比,PNI,CONUT分数).
主要成果:
- 在A组和NA组之间观察到CRP/白蛋白比率,白蛋白/球蛋白比率,PNI和CONUT得分的显著差异.
- 在单变量和多变量分析中,CONUT评分显示了显著的关联.
- 与CONUT分数<5.5的患者相比,具有CONUT分数≥5的患者的截肢风险是2.28倍以上.
结论:
- 在DFS患者中,CONUT得分与截肢有显著的相关性.
- CONUT评分及其严重程度与糖尿病脚截肢有显著的相关性.
- 康得分是DFS截肢风险的重要预测指标,得分≥5表明风险增加2.28倍.
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