概括
心血管疾病死亡率在数十年的下降后再次上升,由肥胖和糖尿病等因素推动. 新的风险预测指标,如apoB和LpA,对于准确的风险评估至关重要.
科学领域:
- 心脏病学和公共卫生
- 慢性病的流行病学 慢性病的流行病学
背景情况:
- 心血管疾病 (CVD) 死亡率从1960年到2020年有所下降,但已经逆转,到2022年将有超过228,000例过度死亡.
- 心血管疾病仍然是发达国家的主要死亡原因,占所有死亡人数的30%以上.
- 成年人患有两种或多种心血管疾病风险因素的患病率正在增加,特别是在老年人群中.
研究的目的:
- 评估现有的心血管疾病 (CVD) 风险计算器.
- 审查常规评估心脏病风险之外的其他风险因素.
- 强调阿波利波蛋白B (apoB) 和脂蛋白A (LpA) 在心血管疾病风险预测中的重要性.
主要方法:
- 审查当前的CVD风险评估策略和计算器.
- 对有关心脏病死亡率趋势和风险因素流行率的流行病学数据的分析.
- 评估新兴生物标志物,如apoB,LpA,全身炎症和胰岛素抵抗.
主要成果:
- 最近观察到心血管疾病死亡率长期下降的反转.
- 成年人群中多重心血管疾病风险因素的患病率正在上升.
- 与单独的LDL水平相比,ApolipoproteinB (apoB) 和脂蛋白A (LpA) 是优越的心血管疾病风险预测剂.
结论:
- 心血管疾病死亡率的上升趋势需要重新评估当前的风险评估工具.
- 结合新的生物标志物,如apoB和LpA,以及系统性炎症和胰岛素抵抗的指标,可以改善心血管疾病风险预测.
- 准确的心血管疾病风险评估对于临床预防策略和保险行业至关重要.
关键词:
阿波利波蛋白B (ApoB) 是一种动脉样硬化心血管疾病 (ASCVD)身体质量指数 (BMI) 是指身体质量指数.心血管疾病 (CVD) 是一种心血管疾病.心血管-脏-代谢 (CKM) 情况.估计的淋巴膜过率 (eGFR)类似葡萄糖类-1受体激动剂 (GLP-1RA)血红蛋白A1c (HbA1c) 是一种高密度胆固醇 (HDL胆固醇) 是一种高灵敏度C反应蛋白 (hs-CRP) 是一种高灵敏度C反应蛋白.中密度脂蛋白 (IDL) 是一种中密度脂蛋白.脂质蛋白 (Lp) [Lp (a)) ]是一种蛋白质.低密度脂蛋白 (LDL) 是一种低密度脂蛋白.聚合的队列方程 (PCEs).糖共传输体-2 抑制剂 (SGLT-2 i)总胆固醇 (TC) 是一种三甘油-葡萄糖 (TyG) 指数指数尿中的白蛋白-肌酸比 (UACR)相关概念视频
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