长期眼内眼科粘弹性器械的安全概况:系统性审查
Rana Khalil1, Diya Shah2, Aman Sutaria2
1Tennent Institute of Ophthalmology, Glasgow, UK rana.khalil@nhs.scot.
The British journal of ophthalmology
|January 20, 2026
概括
眼科粘弹性装置 (OVD) 在眼科手术中至关重要. 基于氨酸 (HA) 的OVD显示出良好的长期安全性,但需要对基甲基纤维素 (HPMC) 和二硫酸盐 (CS) 的OVD进行更多研究.
科学领域:
- 眼科医生 眼科 眼科
- 生物材料科学 生物材料科学
背景情况:
- 50多年来,眼科粘弹性器件 (OVD) 改变了前段手术.
- 由于生物相容性和生物降解性,它们的使用正在扩大到后段手术中作为玻璃体替代品.
- 常见的OVDs使用水友性聚合物,如氨酸 (HA),基甲基纤维素 (HPMC) 和地硫酸盐 (CS).
研究的目的:
- 在眼内外科手术中系统地审查眼科粘弹性装置 (OVD) 长期安全性的文献.
- 评估作为玻璃体替代品使用的OVDs的现有证据.
主要方法:
- 对Medline和Embase数据库进行了系统审查.
- 搜索术语包括"粘弹性"和"内视",没有语言或日期限制.
主要成果:
- 关于OVDs长期眼内安全性的高质量证据很少.
- 包括38项研究,但异质性排除了直接比较,需要进行描述性分析.
- 基于氨酸 (HA) 的OVD是最受研究的,在各种研究中显示出有利的生物物理性质和最小的不良反应.
结论:
- 基于氨酸 (HA) 的OVD在短期和长期眼内应用中表现出良好的安全性.
- 对于基甲基纤维素 (HPMC) 和氏素硫酸盐 (CS) OVDs,尽管它们的使用越来越多,但安全数据显著缺乏.
- 进一步进行高质量的研究对于验证HPMC和CS OVD的安全性和有效性至关重要,特别是对于玻璃甲状腺外科手术和慢性低血压的管理.
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