肺癌查的成本效益:从风险分层,指导方针和新兴技术的见解 - 一个系统的审查
Zijuan Fan1, Manqi Zheng1, Ziyun Guan1
1Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China.
NPJ primary care respiratory medicine
|January 20, 2026
概括
肺癌查,主要使用低剂量计算机断层扫描 (LDCT),对于高危人群来说是具有成本效益的. 有证据支持LDCT.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 公共卫生 公共卫生
背景情况:
- 肺癌仍然是全球癌症死亡的主要原因,晚期诊断是常见的.
- 通过查及早检测对于降低死亡率至关重要.
- 成本效益数据对于为肺癌查政策决策提供信息至关重要.
研究的目的:
- 系统地审查肺癌查的成本效益.
- 评估各种查方式,患者群体和医疗保健机构.
- 为政策指导综合证据.
主要方法:
- 在主要数据库 (PubMed,EMBASE,Web of Science,Cochrane Library) 进行了全面的系统文献搜索,截至2025年3月.
- 在研究选择和数据提取方面遵循了PRISMA指南.
- 包括来自21个国家的79项研究,主要使用高质量的基于模型的分析.
主要成果:
- 低剂量计算机断层扫描 (LDCT) 是主要的查方式,对AI和生物标志物的数据有限.
- 将LDCT与没有查进行比较的14项研究得出了每获得的质量调整寿命年 (QALY) 8376美元至200,921美元之间的增量成本效益比率 (ICER).
- 超过90%的LDCT策略在国家值时被发现具有成本效益,特别是对于老年人和高风险群体;每两年一次的查通常比每年一次更具成本效益.
结论:
- 低剂量计算机断层扫描 (LDCT) 肺癌查显示出有利的成本效益,特别是在定义的高风险人群中.
- 在许多情况下,两年一次的查间隔似乎比年度查更具成本效益.
- 需要进一步的研究来评估新兴的查技术及其在服务不足的地区的成本效益.
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