一种样品制备方法的优化,用于通过三重四极ICP-MS分析确定人类头发中的多元素成分
Agneta Annika Runkel1,2, Marta Jagodic Hudobivnik3, Igor Živković3,4
1Jožef Stefan Institute, Jamova cesta 39, Ljubljana, 1000, Slovenia. agneta.runkel@ijs.si.
Biological trace element research
|January 20, 2026
概括
这项研究开发了一种用于测量人类头发中29种必需和有毒元素的新方法. 经过验证的技术可以提高生物监测暴露时间的准确性和灵敏性.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 人类生物监测 人类生物监测
背景情况:
- 对基本和有毒元素的人类生物监测对于健康风险评估和政策至关重要.
- 人类头发分析提供了一个非侵入性的,长期暴露评估替代血液或尿液.
- 多元元素头发分析的标准化和敏感方法是有限的.
研究的目的:
- 开发和验证一种灵敏,强大的分析方法,用于确定人类头发中的29种元素.
- 为了应对样品准备,污染控制和分析灵敏度方面的挑战.
- 为了实现可重复的多元元素分析,以改善人类暴露的评估.
主要方法:
- 开发了一种涉及洗发 (乙,Milli-Q水),微波消化 (65% HNO3) 和三极四极感应合等离子体质谱 (ICP-MS/MS) 的方法.
- 分析了人类头发的3厘米段,检测29种元素,包括Ag,Al,As,Ba,Ca,Cd,Co,Cr,Cu,Fe,Hg,K,Mg,Mn,Mo,Na,Ni,P,Pb,Rb,S,Sb,Se,Sn,Sr,Ti,U,V和Zn.
- 识别并减轻污染源,如不钢剪刀和不适合的玻璃消化容器.
主要成果:
- 与现有协议相比,优化的方法显示了提高的灵敏度和减少的分析变异性.
- 在样本准备过程中,不钢剪刀被确定为污染的重要来源.
- 经过验证的方法提供了可重现的多元元素分析,提高了头发作为生物监测矩阵的可靠性.
结论:
- 成功开发了一种经过验证,灵敏和强大的方法,用于人类头发的多元元素分析.
- 该研究强调了样本准备过程中的关键污染风险,强调了需要谨慎的技术的必要性.
- 这种方法支持标准化工作,并加强了人类生物监测研究中的暴露评估.
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