阿斯塔丁可以改善缺血性中风后的肠道微生物群和新陈代谢
Chunshu Rong1, Zhen Wei2, Jinjian Li1,3
1Department of Encephalopathy, Hospital of Changchun University of Chinese Medicine, Changchun, 130021, Jilin, China.
Scientific reports
|January 20, 2026
概括
通过调节肠道微生物群和激活AMPK/SIRT1通路,阿斯丁可以预防缺血性中风. 这种天然化合物通过改善能量代谢和改变肠道细菌组成,显示出神经保护的前景.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 缺血性中风是一种主要的脑血管疾病.
- 阿斯塔丁显示出对缺血性中风的保护作用.
- 素在调节中风中的肠道微生物群中的作用尚不清楚.
研究的目的:
- 为了研究素在缺血性中风中的神经保护机制.
- 为了确定阿斯塔克桑对肠道微生物群组成和功能的影响.
- 阐明涉及阿斯塔克桑治疗作用的分子途径.
主要方法:
- 鼠中脑动脉阻塞模型用于缺血性中风.
- 分子对接和动力学来评估阿斯塔克桑与蛋白质的结合.
- 组织病理学 (H&E染色),ELISA,以及用于脑损伤评估的西部斑点.
- 用于肠道微生物群和代谢物分析的16S rRNA测序和非向代谢学.
主要成果:
- 阿斯塔丁的干预显著改变了肠道微生物群的结构,增加了有益的细菌,减少了致病性细菌.
- 阿斯塔克桑治疗导致大脑代谢产物的显著变化.
- 分子对接证实了素与AMPK和SIRT1蛋白质的稳定结合.
- 阿斯塔丁改善了能量代谢,并在缺血性大脑中提高了AMPK/SIRT1表达的调节.
结论:
- 阿斯塔丁对缺血性中风具有神经保护作用.
- 它的机制包括调节肠道微生物群和激活AMPK/SIRT1信号通路.
- 阿斯塔丁显示出作为缺血性中风治疗剂的显著潜力,需要进一步研究.
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