在阿达利穆马布治疗中最大限度地减少遗漏的潜在结核病感染:来自BCG接种队列的真实数据
Fatma Merve Koçak1, Berru Yargı Özkoçak2
1Department of Infectious Diseases and Clinical Microbiology, Beyoğlu Eye Training and Research Hospital, Istanbul, Turkey. drmervekocak@gmail.com.
Clinical rheumatology
|January 20, 2026
概括
像阿达利穆马布 (ADA) 这样的瘤缩因子-α (TNF-α) 抑制剂可以重新激活结核病 (TB). 潜在结核病感染 (LTBI) 查和异化预防可以减少但不能消除ADA患者的结核病风险.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 作为TNF-α抑制剂的Adalimumab (ADA) 对眼部炎症性疾病至关重要.
- 使用ADA与肺结核 (TB) 再激活的风险增加有关.
- 有限的数据存在于潜在结核病感染 (LTBI) 查和接受ADA的患者的结果.
研究的目的:
- 描述在接受ADA治疗的卵膜炎患者中LTBI查结果.
- 为了确定该人群中错过的LTBI病例的模式.
- 评估 LTBI 查和预防在 ADA 治疗期间预防结核病的有效性.
主要方法:
- 对188名被评估是否符合ADA资格的患者的回顾性分析.
- LTBI查包括病史,结核素皮肤测试 (TST),干扰素-释测试 (IGRA) 或组合.
- 在ADA治疗期间对异化 (INH) 预防和结核病发生的评估.
主要成果:
- 贝切特膜炎和肉类发病是最常见的疾病.
- 单独使用TST是60.2%,IGRA是13.4%,两者都在26.3%的基线查中使用.
- 结核病发生在1.6%的患者中,包括两例尽管预防.
结论:
- 通过ADA,LTBI查和预防降低了结核病风险,但并没有消除.
- 结合TST/IGRA查和定期重新评估可能有助于减少遗漏病例,特别是在BCG接种疫苗的个体中.
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