与第二代整合酶链转移抑制剂相关的体重增加的性别和性别差异:范围审查
Tahani Shraida1, Erin Kwak2, Rowan Patterson3
1Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
HIV medicine
|January 20, 2026
概括
第二代整合酶链转移抑制剂 (INSTIs) 与女性体重增加有关. 与异性恋男性相比,异性恋女性的体重增加更为显著,特别是在基于多卢特格拉维尔的疗法中.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 药理学 药理学是指药理学的学科.
- 性别研究是关于性别的研究.
背景情况:
- 体重增加是第二代整合酶链转移抑制剂 (INSTIs) 在抗逆转录病毒治疗中使用的日益关注的问题.
- 现有的文献提出了关于这些体重增加效应是否在性别之间存在差异的混合发现.
研究的目的:
- 审查开始或转向第二代性教育机构的 cisgender 和跨性别女性的体重增加模式,时间,严重程度和风险因素.
- 分析特定INSTIs的数据,如多卢特格拉维尔,比克特格拉维尔和卡博特格拉维尔.
主要方法:
- 在2010-2024年期间对四个数据库 (EMBASE,MEDLINE,Web of Science,CINAHL) 进行了范围审查.
- 包括报告 cisgender 和跨性别女性体重增加的研究或混合队列与性别分类数据的研究.
- 雇佣了三名审查员的独立选和两名审查员的数据提取.
主要成果:
- 审查中包括了40篇文章.
- 大多数研究表明,与服用多卢特格拉维尔或比克特格拉维尔治疗方案的 cisgender 男人相比,cisgender 女人体重增加,尽管存在不一致.
- 在未接受过治疗的 cisgender 女性,黑人女性,非洲环境中的女性以及服用 dolutegravir 与 tenofovir alafenamide 的女性中,体重增加更为明显.
结论:
- 第二代性侵药,特别是杜洛特格拉维尔,与 cisgender 女性的平均和过度体重增加有关.
- 这种效果受到设置,特定的治疗方案和临床背景的影响.
- 进一步的研究至关重要,以了解机制,确定风险因素,并评估不同人群和新药的趋势.
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