在精神分裂症中,大脑和循环的EV蛋白质组签名作为与年龄有关的痴呆症的预后标志物
Jose Antonio Sánchez Milán1,2, Maria Mulet1,2, Itziar Molet1,2
1Lleida Institute of Biomedical Research Foundation Dr. Pifarré: Institut de Recerca Biomedica de Lleida Fundació Dr. Pifarré (IRBLLEIDA) - +Pec Proteomics Research Group (+PPRG) - Neuroscience Area, University Hospital Arnau de Vilanova (HUAV), 80, Av. Rovira Roure, 25198, Lleida, Spain.
Acta neuropathologica communications
|January 21, 2026
概括
精神分裂症患者表现出与年龄相关痴呆症共享的大脑囊泡变化. 这些细胞外囊泡标记可以预测精神分裂症患者的痴呆风险.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症 (SZ) 与与年龄有关的痴呆症 (ARD) 的风险更高,包括阿尔茨海默氏症和血管痴呆症.
- 尚不清楚SZ和ARD之间的分子联系.
- 细胞外囊泡 (EVs) 参与大脑疾病,并可能揭示共享的机制和生物标志物.
研究的目的:
- 通过使用来自大脑的EV (bEV) 来研究SZ和ARD之间共享的分子机制.
- 在循环等离子电动汽车 (pEV) 中验证潜在的生物标志物.
- 根据痴呆症风险概况对SZ患者进行分层.
主要方法:
- 一种两相系统生物学方法,结合蛋白质组学和数据独立采集质谱学 (DIA-MS).
- 从死后SZ和ARD受试者的bEV分析.
- 来自独立的SZ队列的pEV中识别的标记物的验证.
主要成果:
- SZ和ARD bEV在神经元连接性,突触完整性,神经炎症和新陈代谢中表现出重叠的蛋白质和体变化.
- 相关的bEV/pEV标志物将SZ患者分为高和低痴呆风险组.
- 确定了特定的pEV蛋白和作为潜在的循环生物标志物.
结论:
- bEVs是SZ和ARD中共享的神经病原性途径的关键调解者.
- 血EV含有有前途的生物标志物,用于分层SZ患有ARD风险的患者.
- 这些发现为早期检测和干预提供了一种潜在的"从床上到床边"方法.
相关概念视频
Dementia
533
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
533
Schizophrenia
817
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
817
Biological Causes of Schizophrenia
531
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
531
Psychological and Sociocultural Causes of Schizophrenia
491
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
491
Negative and Cognitive Symptoms of Schizophrenia
488
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
488
Positive Symptoms Schizophrenia: Hallucinations and Delusions
510
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
510


