作为与抗体缺乏患者的COVID-19疫苗不响应相关的潜在生物标志物的BAFF-R表达
Eleanor O'Callaghan1, Adrian M Shields2,3, Leon Chang1
1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Clinical and experimental immunology
|January 21, 2026
概括
在B细胞中BAFF-R表达的减少与抗体缺乏的SARS-CoV-2疫苗反应不佳有关. 这表明BAFF-R可能是疫苗失败的生物标志物,并突出了BAFF/BAFF-R轴在免疫力中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- B细胞生物学B细胞生物学
背景情况:
- 抗体缺乏症患者往往对疫苗的反应不足,特别是对SARS-CoV-2的免疫反应.
- 这些患者对疫苗不反应的原因尚不清楚.
- 这项研究调查了B细胞内在因素导致SARS-CoV-2疫苗失败.
研究的目的:
- 为了确定与SARS-CoV-2疫苗失败相关的B细胞内在特征,在抗体缺乏症患者中.
- 探索BAFF-R (B细胞激活因子受体) 表达在疫苗反应中的作用.
主要方法:
- 分析了COV-AD研究中的49名患者的外围B细胞,使用了体外B细胞分化试验.
- 评估了血细胞和血细胞的产生,免疫球蛋白的产生,IGH谱系的多样性和BAFF-R表达.
主要成果:
- 没有反应的人显示IgA类切换免疫球蛋白的产生减少,B细胞分化为血细胞的数量减少.
- 与健康对照人群相比,在大多数不响应者和一些响应者中观察到BAFF-R表面表达的减少.
- 没有检测到替代BAFF受体或血清BAFF升高的补偿上调;IGH谱系多样性得到保留.
结论:
- 降低BAFF-R表达与疫苗不响应相关,表明B细胞潜在的内在缺陷.
- BAFF-R可以作为一种生物标志物,用于识别面临疫苗失败风险的患者.
- BAFF/BAFF-R轴与抗体缺乏个体的疫苗诱导的幽默免疫有关.
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