基于项目响应理论的跨研究可比脆弱指数的开发和评估:来自三个前性队列的见解
Shuai Liu1,2, Guangquan Ran1, Yan Wang1
1Department of Health Related Behaviour and Social Medicine, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
概括
基于物件响应理论 (FI-IRT) 的新脆弱指数提供了对老年人脆弱性的强大和交叉研究可比的衡量标准. 这种先进的脆弱性指数准确地预测死亡风险,并在不同的人口和变量集中保持稳定.
科学领域:
- 老年学是一门学科.
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 累积缺陷的脆弱指数 (FI-CD) 对于预测老年人不良健康结果至关重要.
- 然而,它在交叉研究比较中的使用受到项目同质性的假设的限制.
研究的目的:
- 开发和验证基于项目响应理论 (FI-IRT) 的脆弱性指数,以提高跨研究的可比性.
- 评估FI-IRT与死亡率的关联及其在不同人群和变量集中的稳定性.
主要方法:
- 使用来自三个大型纵向研究的51个健康相关变量构建了一个FI-IRT:CHARLS,HRS和SHARE (2010-2020).
- 在FI-IRT得分估计中采用了双参数后勤 (2PL) 模型.
- 利用Cox/逻辑回归来检查与死亡率的关联,并进行了可靠性检查.
主要成果:
- FI-IRT显示出一个大致正常的分布,脆弱性患病率在队列中从15.5%到28.5%不等.
- FI-IRT与FI-CD有很高的一致性,并且与所有原因的死亡风险增加密切相关 (HRs: 1.81-2.38,P < 0.001).
- 当排除域特定变量时,FI-IRT估计保持稳定,并且在不同亚群中显示出很高的一致性 (ICC:0.945).
结论:
- FI-IRT是一个有价值的,强大的,跨研究可比的脆弱性衡量标准.
- 它提供了更可靠的脆弱性评估及其与老年人死亡率的关联.
- FI-IRT的稳定性增强了它对大规模流行病学研究和临床应用的实用性.
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