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Updated: Jan 22, 2026

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脂质体谷在摄取,细胞再生和系统可用性方面优于普通谷:来自细胞和人类模型的证据
K N Prasad1, Chaithra C1, Yalpi Karthik1
1Samarth Biorigins LLP, KIADB Industrial area, Vasanthanarasapura, Tumkur, Karnataka, India -572 128.
The British journal of nutrition
|January 21, 2026
概括
与标准谷氨相比,一种新的脂质体谷氨配方 (LipoDuoTM) 显著增强了口服吸收和细胞输送. 这种脂质体谷氨显示出改善的抗氧化活性和持续的血水平,为管理氧化应激提供了潜力.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 谷氨是一种重要的细胞内抗氧化剂,对细胞防御机制至关重要.
- 传统谷氨的口服生物可用性较差限制了其治疗应用.
- 脂质体封装是一种克服谷氨输送挑战的策略.
研究的目的:
- 评估一种新型脂质体谷氨配方 (LipoDuoTM) 与普通谷氨的疗效.
- 为了比较细胞吸收,生物活性和*in vivo*系统可用性.
- 评估脂质体谷氨作为一种先进的抗氧化剂补充剂的潜力.
主要方法:
- 使用HEK-293T细胞进行的实验室研究评估了细胞吸收,增殖和伤口愈合.
- 在体内对健康人群 (n=12) 的药理动力学分析,监测了口服后24小时的血谷氨水平.
- 液体染色学-并联质谱学 (LC-MS/MS) 用于血谷量化.
主要成果:
- 与普通谷氨相比,LipoDuoTM的细胞吸收率大约高出1.9倍,细胞增殖和伤口愈合能力优越.
- 口服LipoDuoTM导致Cmax高6倍,血保留时间长 (>500 ng/mL在24小时) 与普通谷氨相比.
- 对脂质体配方观察到双模吸收模式,表明持续释放.
结论:
- LipoDuoTM显著增强了谷氨的细胞输送,生物活性和全身生物可用性.
- 脂质体配方显示出优越的药物动力学特性,包括持续的血水平.
- LipoDuoTM代表了下一代口服抗氧化剂,在管理氧化应激和支持代谢健康方面具有潜在的临床应用.
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