基于导管的心血管医学光学方法:进步,挑战和新方向
Chao Huang1, Nathan Knighton2, Lucas H Timmins2,3
1Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, United States of America.
Progress in biomedical engineering (Bristol, England)
|January 21, 2026
概括
基于导管的光学工具为心血管医学提供了有前途的进展. 这次审查强调了它们在改善心脏移植排斥评估,纤维化映射和引导血管塑性手术等手术方面的潜力.
科学领域:
- 心血管医学 心血管医学
- 生物医学光学 生物医学光学
- 医疗成像医学成像
背景情况:
- 导管治疗对于心血管诊断和治疗至关重要.
- 了解心脏组织的光学特性 (散射,吸收,光) 是关键.
- 现有的临床工具在实时组织表征方面存在局限性.
研究的目的:
- 审查心血管医学以导管为基础的光学工具的发展.
- 探索用于心脏组织表征的光学模式的应用.
- 评估将这些工具转化为临床实践的潜力和挑战.
主要方法:
- 概述心脏解剖学和光学特性.
- 介绍光学方式:光谱,显微镜 (共聚焦,多光子,光片) 和光学连贯性断层扫描.
- 应用程序的调查,包括心脏移植排斥,心房纤维化映射,导管切除和冠状动脉干预.
主要成果:
- 基于导管的光学工具显示出评估心脏移植排斥的潜力,超越了内肌心活检的局限性.
- 光学方法可以帮助绘制心房纤维化映射,这对于预测心房的预后至关重要.
- 这些工具为导管切除,冠状动脉血管塑造和支架安置提供了改进的指导.
结论:
- 基于导管的光学工具具有显著的潜力,可以提高心血管医学中的诊断和治疗.
- 需要进一步的研究来解决成功临床翻译的技术挑战.
- 这些先进的光学方法有望改善心脏护理中的患者结果.
相关概念视频
Cardiovascular Drugs: Classification based on Therapeutic Indications
4.1K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.1K
Overview of the Cardiovascular System
10.9K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
10.9K
Regulation of the Cardiovascular System
3.8K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
3.8K
Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
Microorganisms in Medicine and Therapeutics
1.0K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.0K
Exercise and Cardiovascular Response
3.9K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.9K


