脱脂症对胚胎质量和生殖结果的不良影响在经历第一次试管婴儿/ICSI周期的特定亚组:一个病例对照研究
Jiahuan Luo1,2, Dandan Zhang2, Jinyuan Wang2
1Reproductive Center Obstetrics and Gynecology, Xinqiao Hospital, Chongqing, China.
Medicine
|January 21, 2026
概括
脱脂症会影响体外受精的结果,特别是影响年轻女性.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症研究 不孕症研究
- 代谢健康和生育能力
背景情况:
- 脱脂症是一种常见的代谢障碍,可能会影响生育治疗.
- 了解其对体外受精/细胞内精子注射 (IVF/ICSI) 的影响对于优化患者护理至关重要.
- 年龄,BMI和脂质水平的修改效应需要进一步调查.
研究的目的:
- 评估女性进行第一次卵巢刺激时的脂质不良症和IVF/ICSI结果之间的关联.
- 为了确定年龄,体重指数 (BMI) 或特定脂质水平是否会改变这些关联.
- 评估对胚胎质量,临床怀孕和活产率等关键生育指标的影响.
主要方法:
- 回顾性队列研究,包括327名患有脱脂症的妇女和756名正常脂质样本的妇女.
- 分析了2016年4月至2023年3月期间第一次试管婴儿/ICSI周期的数据.
- 采用了通用线性模型和子组分析,并对潜在的混因素进行了调整.
主要成果:
- 总的来说,脂质不良并没有显著影响高质量的切割胚胎率,累计临床怀孕率 (CCPR) 或累计活产率 (CLBR).
- 脱脂症与较低的卵细胞检索率有关 (P=.025).
- 亚组分析显示了与老年女性 (≥35岁) 卵细胞检索,年轻女性 (<35岁) CCPR/CLBR和肥胖女性 (BMI ≥28 kg/m2) 裂解率的负相关性. 边际升高的甘油三与较低的卵细胞检索相关.
结论:
- 脱脂症与IVF/ICSI接受治疗的年轻女性的累积活产率和临床怀孕率降低有关.
- 它对老年妇女的卵细胞检索率和肥胖妇女的分离率产生负面影响.
- 边际上升的甘油三水平与减少卵细胞检索相关,需要进一步调查.
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