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饮食中和脂肪酸摄入量与类风湿性关节炎之间的关联:基于NHANESES的横截面研究

Jianyun Xu¹, Yangfan Wang, Qi Rao

¹Qichun County People's Hospital, Huanggang, Hubei Province, China.

|January 21, 2026

概括

较低的和脂肪酸 (SFA) 摄入量与风湿性关节炎 (RA) 的风险降低有关. 这项研究发现了显著的负相关性,表明SFA可能起到预防RA发展的保护作用.

科学领域:

营养科学营养科学
类风湿病学类风湿病学
流行病学流行病学

背景情况:

类风湿性关节炎 (RA) 是一种具有复杂病因的慢性自身免疫性疾病.
饮食因素,包括和脂肪酸 (SFA) 摄入量,正在越来越多地研究它们在RA病变发生中的作用.

研究的目的:

调查和脂肪酸 (SFA) 摄入量与患类风湿性关节炎 (RA) 的风险之间的关联.
探索饮食模式对RA风险的潜在保护作用.

主要方法:

一项横截面研究利用了国家健康和营养检查调查 (2003-2023) 中15885名参与者的数据.
使用多变量逻辑回归,接收器操作特征 (ROC) 曲线,灵敏度分析和受限立方线分析.
调整了包括年龄,性别,BMI,吸烟和酒精摄入量在内的混因素.

主要成果:

在SFA摄入量和RA风险之间观察到显著的负相关性 (OR=0.801,P<.001).
在对多个混变量进行调整后,这种关联仍然显著 (模型2 OR=0.872,P=.023;模型3 OR=0.798,P=.002).
确定了SFA摄入量和RA风险之间的非线性关系 (P为非线性=0.0273),ROC分析证实了结果的稳定性 (AUC=0.78).

结论:

较低的和脂肪酸 (SFA) 摄入量与风湿性关节炎 (RA) 的风险降低有关.
饮食中的SFA可能会对RA发展产生保护作用.
进一步研究RA预防的饮食干预措施是有必要的.

关键词:

国家健康和营养检查调查调查回归模型是一种回归模型.有限制的立方线.类风湿性关节炎类风湿性关节炎和脂肪酸摄入量和脂肪酸摄入量

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