老年患者的血清HMGB1水平,接受了用德克斯梅德托米丁进行全身麻醉的患者,及其与早期术后认知功能障碍的相关性
Hanmei Zhou1, Lei Li1, Xiaorui Guo1
1Department of Anesthesiology, The Third People's Hospital of Chengdu, Southwest Jiao Tong University, Chengdu, China.
Medicine
|January 21, 2026
概括
在接受全身麻醉的老年患者中使用德克斯梅德托米丁与早期认知功能的改善和高流动性组盒1 (HMGB1) 的降低水平有关,HMGB1是术后认知功能障碍的潜在生物标志物.
科学领域:
- 麻醉学 麻醉学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 手术后认知功能障碍 (POCD) 是老年患者的一个重大问题.
- 高流动性组框1 (HMGB1) 与炎症反应和神经元损伤有关.
研究的目的:
- 在全身麻醉后对老年患者的血清HMGB1水平研究德克斯梅德托米丁的作用.
- 探索HMGB1和早期认知功能障碍之间的相关性.
主要方法:
- 对108名接受整体手术的老年患者进行前性队列研究.
- 在手术前和手术后测量血清HMGB1,CRP,IL-6,IL-1β.
- 使用迷你精神状态检查 (MMSE) 成绩评估认知功能.
主要成果:
- 在手术后24小时,德克斯梅德托米丁组的MMSE得分显著更高.
- 血清HMGB1,IL-6和IL-1β水平在德克斯梅托米丁组中较低.
- 较低的MMSE得分与较高的HMGB1,IL-6和IL-1β水平相关.
结论:
- 在麻醉后的老年患者中,德克斯梅德托米丁可降低血清中的HMGB1,IL-6和IL-1β水平.
- HMGB1可能是早期术后认知功能障碍的风险因素和潜在生物标志物.
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