免疫球蛋白G4相关的多器官疾病:一个病例报告
Jing Qiao1, Xiaoxia Xu1, Ze Wang1
1Department of Gastroenterology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
Medicine
|January 21, 2026
概括
本病例报告详细介绍了一种罕见的多器官免疫球蛋白G4相关疾病 (IgG4-RD),影响胃肠道,胰腺和肝脏. 早期诊断和葡萄糖皮质激素治疗导致了显著的临床改善,强调了识别IgG4-RD多种表现的重要性.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
背景情况:
- 免疫球蛋白G4相关疾病 (IgG4-RD) 是一种罕见的疾病,其特征是血清IgG4和IgG4阳性血细胞透率升高.
- 多器官参与,特别是在胃肠道,是不常见的,但呈现诊断挑战.
研究的目的:
- 报告一种罕见的多器官IgG4-RD病例,涉及胃肠道,胰腺和肝脏.
- 提高临床医师对IgG4-RD多种表现的认识,减少误诊和不必要的手术.
主要方法:
- 一名76岁的女性出现腹痛,黄,血清IgG4升高,肝功能测试异常.
- 图像检查显示胆道扩张和胰腺/胆道狭窄;胃镜显示炎症.
- 组织病理学证实IgG4-RD在胃,胰腺和肝脏活检中具有高IgG4/IgG血细胞比率.
主要成果:
- 该患者被诊断出患有影响胰腺,胆道,肝脏和胃肠道的IgG4-RD.
- 使用口服普得尼松酸盐治疗导致黄,肝功能测试和血清IgG4水平显著改善.
- 随访成像和胃镜显示病情有所改善.
结论:
- IgG4-RD具有不同的临床表现,可以影响多个器官.
- 误诊是常见的,可能导致不必要的外科干预.
- 及时诊断和适当的皮质糖类药物治疗对于有效管理IgG4-RD至关重要.
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