通过可解释的机器学习模型探索全血细胞计数衍生的炎症生物标志物和癌症发病率之间的关联:基于NHANES 1999至2016年的研究
Sijun Zhao1, Ping Fu1, Liangqing Lin1
1Department of Traumatology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China.
全血细胞计数 (CBC) 衍生的炎症标志物如SIRI,NLR,MLR和NMLR与癌症风险增加有关. 可解释的机器学习揭示了复杂的非线性关系,表明了改进癌症检测的潜力.
科学领域:
- 生物医学研究的研究.
- 计算生物学是一种计算生物学.
- 在瘤学瘤学.
背景情况:
- 炎症在癌症的发展和进展中起着重要作用.
- 完整血细胞计数 (CBC) 参数可以反映系统性炎症.
- 现有的研究经常使用传统的统计方法,可能缺少复杂的生物标志物关系.
研究的目的:
- 通过可解释的机器学习研究CBC衍生的炎症标志物与癌症发生之间的关联.
- 为了确定特定的炎症生物标志物预测癌症风险.
- 探索这些标志物对癌症患病率的非线性关系和潜在值影响.
主要方法:
- 分析了35591名参与国家健康和营养检查调查 (1999-2016) 的数据.
- 对四种CBC衍生的炎症生物标志物的检查:SIRI,NLR,MLR和NMLR.
- 应用加权多变量逻辑回归,受限立方线模拟和子组分析.
- 使用了8个机器学习算法,Boruta特征选择和SHAP用于解释性.
主要成果:
- 患有癌症的参与者显示所有检查的炎症标志物的水平显著更高.
- 最高四分位数的SIRI,NLR,MLR和NMLR与显著增加的癌症风险相关 (ORs从1.26到1.44).
- 在所有生物标志物中观察到显著的积极剂量反应趋势和非线性关联与确定的拐点.
- 随机森林模型实现了0.765的AUC,年龄,MLR,淋巴细胞计数和NMLR被SHAP分析确定为关键预测因子.
结论:
- 来自CBC的炎症生物标志物与癌症患病率有显著的非线性关联.
- 可解释的机器学习模型揭示了超越传统方法的复杂关系.
- 这些可访问的生物标志物有望增强癌症风险分层和早期检测策略.
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