解码人类胎盘细胞和分子对肥胖和胎儿生长的反应
Hong Jiang1,2, Emilie Derisoud1, Denise Parreira1,2
1Karolinska Institutet, Department of Physiology and Pharmacology, Stockholm, Sweden.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 21, 2026
概括
孕产妇的肥胖会影响胎盘基因表达,特别是在响应孕期大出生 (LGA) 的细胞中. 这些发现揭示了与母亲肥胖和胎儿生长结果相关的特定胎盘特征.
科学领域:
- 生殖生物学 生殖生物学
- 基因组学就是基因组学.
- 代谢健康 代谢健康
背景情况:
- 孕产妇的肥胖与不良的妊娠结果有关,例如对孕期大 (LGA) 的出生.
- 肥胖母亲的后代面临心脏代谢疾病的风险增加.
- 胎盘适应可能会调解母亲肥胖对胎儿发育的影响.
研究的目的:
- 为了识别与孕产妇肥胖和LGA分娩相关的胎盘基因表达特征.
- 在孕产妇肥胖和胎儿生长的背景下,比较胎盘细胞特异反应.
- 调查将孕产妇肥胖与胎盘功能障碍联系在一起的潜在机制.
主要方法:
- 来自肥胖妇女的胎盘单核RNA测序 (分娩适合妊娠年龄或LGA婴儿) 和正常体重的对照.
- 分析合成细胞,细胞细胞和状非细胞中的基因表达模式.
- 利用微流体器官在芯片上的系统来模拟胎盘细胞的反应.
主要成果:
- 孕产妇的肥胖导致高调低氧和TNF-α信号在syncytiotrophoblasts,无论胎儿的生长.
- 细胞质体显示了受体氨酸激酶信号的下调.
- 状非热原体和霍夫尔细胞表现出高调的炎症和免疫代谢基因表达,特别是在LGA胎盘中.
- 霍夫尔细胞中SPP1表达升高表明潜在的细胞间信号传递.
结论:
- 孕产妇的肥胖会导致明显的胎盘细胞特异性转录变化.
- 特定的胎盘特征,特别是在状非热原体和霍夫尔细胞中,与LGA出生有关.
- 这些发现突出了研究母亲肥胖对怀孕结果和后代健康影响的途径.
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