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Updated: Jan 22, 2026

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原子精度三重酶纳米酶同步线粒体双通路干扰用于精密瘤学
Yufan Zhang1, Shuangshuang Yang1, Qin Xiang1
1Marshall Laboratory of Biomedical Engineering, Research Center for Biosensor and Nanotheranostic, School of Biomedical Engineering, Health Science Center, Shenzhen University, Guangdong, 518060, P.R. China.
Angewandte Chemie (International ed. in English)
|January 21, 2026
概括
研究人员开发了一种新型纳米酶,精确地准线粒体,破坏癌细胞能量和氧化还原平衡. 结合基因沉默,它在乳腺癌模型中实现了显著的瘤回归.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 在瘤学瘤学.
背景情况:
- 通过纳米酶介导的线粒体平衡的破坏提供了治疗潜力,但缺乏精确的控制.
- 单一功能催化剂阻碍了纳米酶活动的时空调节.
研究的目的:
- 设计一种多功能纳米酶,以精确地调节线粒体恒常的时空调节.
- 为癌症治疗开发具有协同作用的酶活性的原子精度催化剂.
主要方法:
- 在Pd纳米立方体内核上制造一个具有三基啡因功能化的Pd@PtIr纳米酶,并配有表轴性Pt-Ir合金外.
- 使用密度函数理论 (DFT) 来验证增强的过氧化酶类活性.
- 使用近红外 (NIR) 辐射来触发瘤细胞内的酶模仿性氧化还原反应.
主要成果:
- 该纳米酶表现出增强的过氧化酶样,NADH氧化酶和谷甲过氧化酶样活动.
- 尼尔射线辐射诱导了线粒体谷氨耗尽,反应性氧物种 (ROS) 升高,并破坏了ATP生物合成.
- 与ASncmtRNA沉默的联合治疗导致89.1%的瘤回归在一个正位素乳腺癌模型中.
结论:
- 合理设计的纳米酶提供了多功能酶活性,用于精确的有机细胞向.
- 这种纳米酶设计和基因沉默的综合方法为瘤学中精密纳米疗法提供了一个新的范式.
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