普罗萨波辛是一种双重作用的治疗点,用于血管稳定和神经保护
Jianhao Bai1, Sijie Li2, Aiting Wang2
1Department of Ophthalmology, Shanghai East Hospital, School of Medicine, Tongji University 150 Jimo RD, Pudong District, Shanghai, 200120, China; Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University 301 Yanchang RD, Jingan District, Shanghai, 200072, China.
概括
普罗萨波辛 (Prosaposin) 是一种新型治疗眼睛疾病的有希望的药物,例如湿与年龄相关的黄斑变性. 它有效地减少了血管泄漏,并保护视网膜细胞,为那些对当前治疗无反应的患者提供了希望.
科学领域:
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 血管本位异常的血管疾病会破坏血管平衡.
- 目前的抗血管内皮生长因子 (VEGF) 疗法在某些患者的疗效有限.
研究的目的:
- 为了识别 fundus 异常血管疾病的新型治疗点.
- 评估普罗萨波辛作为这些疾病的潜在治疗方法.
主要方法:
- 从患有 fundus 异常血管疾病的患者获得的 173 个水性样的蛋白质组分析.
- 在体外试验测试以评估普罗萨波辛对内皮功能障碍和血管透性的影响.
- 在体内对70个样本的独立队列进行体内研究,以评估抗血管性,抗炎和神经保护作用.
主要成果:
- 普罗萨波辛被确定为一种潜在的治疗候选药物.
- 在体外,普罗萨素减少了内皮功能障碍和血管透性.
- 在体内,普罗萨波辛表现出抗血管和抗炎作用,减少了血管泄漏和视网膜,并提供神经保护.
结论:
- 普罗萨波辛在维持血管平衡和保护神经组织方面发挥了双重作用.
- 普罗萨波辛 (Prosaposin) 是一种潜在的替代治疗方法,用于患有底部异常血管疾病的患者,这些患者对抗VEGF疗法没有反应.
相关概念视频
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
179
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
179
Targets for Drug Action: Overview
10.1K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.1K
Nuclear Stability
22.9K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
To hold positively charged protons together...
22.9K
RNA Stability
35.6K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.6K
Fixed Action Patterns
17.5K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.5K
Stability
392
The time response of a linear time-invariant (LTI) system can be divided into transient and steady-state responses. The transient response represents the system's initial reaction to a change in input and diminishes to zero over time. In contrast, the steady-state response is the behavior that persists after the transient effects have faded.
The stability of an LTI system is determined by the roots of its characteristic equation, known as poles. A system is stable if it produces a bounded...
The stability of an LTI system is determined by the roots of its characteristic equation, known as poles. A system is stable if it produces a bounded...
392


