在亚洲患有代谢功能障碍相关的性肝病的亚洲患者中,性肝病相关的纤维化估计得分
Kunhee Kim1, Hye Won Lee1,2,3, Jae Seung Lee1,2,3
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yonsei medical journal
|January 21, 2026
概括
安全得分有效预测亚洲患者的肝纤维化与代谢功能障碍相关的脂肪性肝病. 这一分数显示了初级保健机构初步风险评估的前景.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
- 诊断的准确性 诊断的准确性
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题.
- 准确的非侵入性纤维化评估对于管理MASLD至关重要.
- 石症相关纤维化估计器 (SAFE) 评分是为了在初级保健中显著预测纤维化而开发的.
研究的目的:
- 在一个有 MASLD 的亚洲人口中对 SAFE 评分的表现进行外部验证.
- 将SAFE评分的诊断准确性与现有的纤维化评估工具进行比较.
主要方法:
- 分析了一组6229名患有MASLD的亚洲患者,这些患者在2012年至2022年期间接受过渡性弹性图 (TE).
- 用SAFE评分的灵敏度,特异性,负预测值和正预测值计算,用于预测纤维化阶段≥2使用两个切断值 (<0和≥100).
主要成果:
- 安全得分显示了良好的诊断性能,接收器操作特征曲线 (AUC) 下的面积为0.753,超过纤维化-4 (AUC 0.672) 和NAFLD纤维化得分 (AUC 0.663).
- 在非肥胖和肥胖患者之间,SAFE分数截止值的绩效指标是可比的.
- 对SAFE分数切线≥100的敏感性随着年龄的增长而增加,而特异性则下降.
结论:
- 该SAFE评分是验证和有效的工具,用于预测有 MASLD 的亚洲患者显著的肝纤维化.
- SAFE评分显示了其作为初始,非侵入性评估工具的潜力,用于识别初级保健机构中低风险个体.
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