Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

490
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
490
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

486
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
486
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

426
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
426
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

520
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
520
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

320
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
320
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

357
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
357

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Revisiting Predicted Age of Disease Onset in a Korean Kindred with the Transthyretin Asp38Val Variant.

Korean circulation journal·2026
Same author

Mitral Annular and Aortic Calcification in Aortic Stenosis: Risk Marker or Bystander?

Korean circulation journal·2026
Same author

Resolving a Complex Neonatal Phenotype by Rapid Trio Whole-Genome Sequencing: A De Novo 11q14.3-q22.3 Deletion and a Splicing-Altering Synonymous ANK1 Variant.

Journal of clinical laboratory analysis·2026
Same author

Correction to: Whole Genome Sequencing in 25 Families with Suspected Inborn Errors of Immunity: Diagnostic Yield and Clinical Relevance of Genome-wide Analysis.

Journal of clinical immunology·2026
Same author

High-urgency heart transplantation and outcome trade-offs: early post-transplant infection and mortality.

ESC heart failure·2026
Same author

Prognostic Value of Exercise-Induced Left Ventricular Functional Reserve Assessed by Left Ventricular Global Strain in Heart Failure With Preserved Ejection Fraction.

Korean circulation journal·2026

相关实验视频

Updated: Jan 22, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.3K

在扩展性心肌病中基因型驱动的预测.

David Hong1, Young-Gon Kim2, Seung Hyeok Bang1

  • 1Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Korean circulation journal
|January 21, 2026
PubMed
概括

扩张性心肌病 (DCM) 的遗传检测可以识别患有心脏不良事件风险较高的患者. 基因型阳性DCM患者面临的结果明显更差,突出遗传测试.

关键词:
扩展性心肌病变性是指扩展性心肌病变性遗传学 遗传学是一种遗传学.心脏衰竭是因为心脏衰竭.预测 预后 预测 预测

更多相关视频

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.9K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.3K

相关实验视频

Last Updated: Jan 22, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
05:14

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Published on: May 16, 2020

5.3K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.9K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.3K

科学领域:

  • 心脏病学 心脏病学
  • 遗传学 遗传学是一种遗传学.
  • 基因组学就是基因组学.

背景情况:

  • 扩展性心肌病 (DCM) 与可变且往往预后不佳的情况有关.
  • 遗传因素显著影响DCM的发展和进展.
  • 识别高风险DCM患者对于及时干预至关重要.

研究的目的:

  • 评估基因检测对诊断为DCM的患者的预后影响.
  • 为了确定基因变异是否与DCM患者的不良心脏结果相关.

主要方法:

  • 对239名DCM患者进行遗传测序 (2018-2023) 的回顾性分析.
  • 被归类为基因型阳性 (致病性/可能致病性变体) 或基因型负的患者.
  • 主要结局:心脏死亡,心脏移植或5年后LVAD植入组合.

主要成果:

  • 基因型阳性DCM患者 (33.1%) 显示主要结局的风险明显更高 (HR 1.80,p=0.020).
  • 从没有VUS变体到基因型阳性群体 (p=0.032) 观察到不良事件的逐步增加.
  • 根据受影响的功能基因组 (p=0.003) 的基因型阳性患者,结果在基因型阳性患者中有显著差异 (p=0.003).

结论:

  • DCM的预后受到遗传状态的显著影响.
  • 基因检测可以帮助分层DCM患者的风险.
  • 需要进一步的研究来优化DCM中遗传测试的临床应用.