相关实验视频
Updated: Jan 22, 2026

11:19
Spatiotemporal Analysis of Cytokinetic Events in Fission Yeast
Published on: February 20, 2017
7.7K
对裂变酵母染色体大小决定因素的研究
Pei-Shang Wu1, Todd Fallesen2, Frank Uhlmann1
1Chromosome Segregation Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
Journal of cell science
|January 21, 2026
概括
染色体大小各不相同,但细胞大小和线粒分裂的持续时间并不是关键因素. 相反,染色体凝聚酶复合体的数量直接影响染色体尺寸,揭示了一个内在的控制机制.
科学领域:
- 细胞生物学 细胞生物学
- 遗传学 是一个遗传学.
- 显微镜的使用方法
背景情况:
- 染色体尺寸表现出物种和阶段特定的变化.
- 控制染色体大小的生理因素尚未得到充分理解.
研究的目的:
- 为了研究裂变酵母Schizosaccharomyces pombe的染色体大小的决定因素.
- 阐明细胞/线粒体参数与染色体尺寸之间的关系.
主要方法:
- 使用超高分辨率显微镜进行详细的成像.
- 使用半自动测量来量化染色体尺寸.
- 分析了不同凝素复合物水平对染色体大小的影响.
主要成果:
- 间期细胞或核体积对染色体尺寸的影响最小.
- 线粒分裂的持续时间对得到的染色体大小几乎没有影响.
- 染色体凝聚酶复合体水平的增加导致染色体更紧,更短,更薄.
结论:
- 染色体大小主要是由内在机制决定的,特别是染色体凝聚酶复合物的水平.
- 环境因素,如细胞体积或线粒分裂的持续时间,在定位染色体尺寸方面发挥的作用较小.
相关概念视频
Nuclear Fission
12.3K
Many heavier elements with smaller binding energies per nucleon can decompose into more stable elements that have intermediate mass numbers and larger binding energies per nucleon—that is, mass numbers and binding energies per nucleon that are closer to the “peak” of the binding energy graph near 56. Sometimes neutrons are also produced. This decomposition of a large nucleus into smaller pieces is called fission. The breaking is rather random with the formation of a large...
12.3K
The Y Chromosome Determines Maleness
7.9K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
7.9K
Lampbrush Chromosomes
8.6K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
8.6K
Chromosome Structure
26.0K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
26.0K
Chromosome Replication
10.5K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins. This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.5K
Polytene Chromosomes
10.9K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
10.9K

