肠-关节轴:调查功能性胃肠道疾病作为假肢关节感染的风险因素,进行了回顾性病例控制研究
Dongsheng Guo1,2, Yang Song3, Liufeng Yuan3
1Department of Joint Surgery, Lianyungang Clinical Medical College of Nanjing Medical University, Lianyungang, China.
Postgraduate medicine
|January 21, 2026
概括
功能性便秘是全关节整形手术 (TJA) 后周围假肢关节感染 (PJI) 的新发现的独立风险因素. 功能性胃肠道疾病的查可以改善对PJI的患者风险评估.
科学领域:
- 整形外科 整形外科 整形外科
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 周围假肢关节感染 (PJI) 是全面关节整形术 (TJA) 后的一种严重并发症.
- 传统的危险因素包括糖尿病和肥胖.
- 新兴研究表明,功能性胃肠道疾病 (FGID) 可能会影响全身炎症和感染风险.
研究的目的:
- 调查先前存在的FGID是否是PJI的独立风险因素.
- 确定与增加PJI风险相关的特定FGID.
主要方法:
- 对896名接受初级TJA (2013-2023) 的患者进行了回顾性病例对照研究.
- PJI病例 (n=448) 与非PJI对照 (n=448) 的 1:1匹配.
- 使用罗马四号标准分类的FGID; 通过2018年肌肉骨感染学会标准诊断的PJI; 用于分析的多变量逻辑回归.
主要成果:
- 功能性便秘 (FC) 在PJI病例中明显更为普遍 (14.3%与8.3%,p=0.0043).
- 多变量分析证实FC作为一个独立的PJI风险因素 (OR=1.844,p=0.0059),与糖尿病和更长的手术持续时间 (>2小时) 一起.
- 在外科手术期间使用抗生素与PJI风险降低有关 (OR=0.405,p=0.0010).
结论:
- 功能性便秘是一种新的,独立的PJI风险因素.
- 这些发现突出显示了PJI病变发生过程中的肠关节轴.
- 建议将FGID查纳入TJA患者的手术前风险分层.
相关概念视频
Functional Classification of Joints
6.6K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
6.6K
Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Structural Joints: Synovial Joints
6.5K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
6.5K
Structural Joints: Fibrous Joints
3.6K
Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
3.6K
Structural Joints: Cartilaginous Joints
3.9K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
3.9K
Joints
35.5K
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.5K


