在一个重建的人类表皮模型中,利用红葡萄葡萄汁提取物来实现可持续的广谱光保护
Antonella Smeriglio1, Marta Mangano1, Mariarosaria Ingegneri1
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, Messina, Italy.
Frontiers in pharmacology
|January 21, 2026
概括
红葡萄葡萄汁提取物 (GPE) 提供强大的抗氧化和抗炎功效. 这种可持续的成分有效地保护皮肤免受紫外线损伤,使其成为先进皮肤化品配方的理想选择.
科学领域:
- 皮肤化学和营养保健品
- 可持续化学和副产品的价值化
- 光保护和皮肤生物学
背景情况:
- 红葡萄葡萄汁是酒的副产品,富含生物活性多.
- 现有研究强调了葡萄衍生化合物在化品和健康方面的潜力.
- 需要可持续的,高价值的成分用于护肤应用.
研究的目的:
- 开发和描述一个标准化的葡萄末提取物 (GPE).
- 评估GPE的抗氧化,抗炎和光保护性质.
- 评估GPE在UV保护的化品配方中的安全性和有效性.
主要方法:
- 使用LC-DAD-ESI-MS/MS进行植物化学分析.
- 在体外抗氧化剂测试 (FRAP,ORAC) 和抗炎试验.
- 在体外光保护研究重建的人类表皮 (RHE) 模型暴露于UVA/UVB辐射.
主要成果:
- GPE中含有大量的安托西亚宁,林,斯蒂尔和黄醇.
- 提取物在体外表现出强烈的抗氧化和抗炎活性.
- GPE及其化品配方 (SS + GPE) 显著降低了UV诱导的氧化应激和炎症,同时保持了细胞活力.
- 组织学分析证实了表皮结构保护和角质化正常化.
结论:
- 标准化GPE是一种安全,光稳定和多功能生物活性成分.
- GPE有效地抵消紫外线诱导的氧化和炎症损伤.
- 上循环的红葡萄葡萄汁提供了高价值皮肤化品配方的可持续来源,具有广泛的光保护功效.
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