沃里康纳相关的肝损伤:临床风险因素的识别和预测性诺莫格拉姆构建
Dongge Feng1,2, Yiyi Ma1, Xiaoyi Liu1,2
1Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Frontiers in pharmacology
|January 21, 2026
概括
同时使用ezetimibe,caspofungin,葡萄糖皮质类药物和高总胆固醇 (TC) 是伏利康纳引起的肝损伤的关键风险因素. 开发了一个预测性名录,以提高药物安全性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 临床医学 临床医学
背景情况:
- 沃里康纳是一种重要的抗真菌剂.
- 药物诱导性肝损伤 (DILI) 是沃里康纳治疗的一个重大问题.
- 优化voriconazole的安全性需要了解其风险因素.
研究的目的:
- 为了确定沃里可纳诱导的肝损伤 (VILI) 的高风险因素.
- 为VILI风险开发一个预测性名录.
- 为了提高voriconazole药物的临床安全性.
主要方法:
- 对768名用voriconazole治疗的患者的电子健康记录进行了回顾性分析.
- 统计分析包括单变量查,LASSO回归和多变量逻辑回归.
- 使用ROC分析,校准曲线和DCA.开发和内部验证预测名录.
主要成果:
- VILI的发生率为12.4% (95名患者).
- 确定了独立的危险因素:同时使用埃泽胺,类,葡萄糖皮质类药物,以及总胆固醇 (TC) 水平>4.485 mmol/L.
- 预测名录显示了良好的区分 (AUC = 0.728) 和校准.
结论:
- 埃泽蒂米布,卡斯波丁,葡萄糖皮质类药物和TC升高是VILI的重要危险因素.
- 开发的诺米图谱为VILI风险提供了临床上有用的预测.
- 这种工具可以帮助优化伏利康纳治疗,提高患者的安全性.
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