系统性炎症指数调解了高尿血和左心室缩之间的关联:来自单中心回顾性横截面研究的证据
Jingyuan Li1, Yang Xu1, Ruting Li2
1Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, Qingdao, China.
Frontiers in endocrinology
|January 21, 2026
概括
通过SII和SIRI测量的系统性炎症与患有高尿血症 (HUA) 的患者的左心室缩 (LVH) 有关. 这些炎症标志物部分解释了高尿酸水平如何影响心脏重塑.
科学领域:
- 心脏病学 心脏病学
- 炎症研究的研究.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 高尿路血 (HUA) 与左心室缩 (LVH) 有关,这是心脏损伤标志物.
- 系统性炎症与心室重塑有关.
- 系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 可以量化炎症.
研究的目的:
- 在HUA患者中调查SII,SIRI和LVH之间的关联.
- 探索系统性炎症在血清尿酸和LVH之间的关系中的作用.
主要方法:
- 对3632名HUA患者的分析,不包括高血压,糖尿病或晚期CKD患者.
- 计算和SII和SIRI的日志转换,然后进行k-means集群.
- 后勤回归,受限立方线和调解分析来评估关联和路径.
主要成果:
- 12.5%的患者患有LVH,与年龄较大,女性性别,高SBP,尿酸,葡萄糖,SII,SIRI和较低的eGFR,LVEF相关.
- 升高的SII和SIRI独立地与LVH相关.
- 系统性炎症部分介导了尿酸酸-LVH关系 (11.9%的SII,SIRI的29.9%).
结论:
- 在HUA患者中,SII和SIRI与LVH正相关.
- 系统性炎症在尿酸酸-LVH关系中起着部分调解作用.
- 突出了炎症在与高尿血症相关的心血管疾病中的重要性.
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