,

Debora Chiodi1, Yoshihiro Ishihara2

  • 1Department of Chemistry, Takeda Pharmaceuticals 9625 Towne Centre Drive San Diego CA 92121 USA.

RSC medicinal chemistry
|January 21, 2026
PubMed
概括

(Cl) 和甲氧 (OCH3) 替代剂,尽管具有相反的电子效应,但表现出类似的双电静态行为. 这种多功能性使他们能够探测蛋白质口袋用于药物发现,并优化连接体-蛋白质相互作用.

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