肠道微生物群及其在自闭症谱系障碍中的代谢:从致病源到治疗
Wanping Bu1, Zhichuan Chen2, Bo Liu3
1School of Clinical Medicine, Quanzhou Medical College, Quanzhou, Fujian, China.
Frontiers in cellular and infection microbiology
|January 21, 2026
概括
自闭症谱系障碍 (ASD) 与肠道细菌的变化有关. 恢复肠道微生物群平衡可能会改善自闭症症状,但对于个性化治疗需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出社会沟通缺陷和重复性行为.
- 胃肠道症状影响了近一半的自闭症患者,这表明肠-大脑轴连接.
- 肠道微生物群的改变与ASD的发病有关.
研究的目的:
- 审查肠道微生物群在自闭症谱系障碍中的作用.
- 在ASD中探索肠-大脑轴的机制.
- 要总结针对ASD的微生物向干预措施.
主要方法:
- 关于自闭症谱系障碍和肠道微生物群的研究文献综述.
- 在ASD中分析微生物多样性,组成和代谢物概况.
- 检查肠-大脑轴调节通路的检查.
主要成果:
- 自闭症患者表现出肠道微生物多样性减少和改变的细菌体/细菌体比率.
- 肠道微生物群的代谢物 (SCFA,胆酸等) 通过BBB透性,神经炎症和神经递质平衡来调解ASD症状.
- 肠-大脑轴涉及HPA轴,迷走神经,免疫系统和屏障功能.
结论:
- 针对肠道微生物群的干预措施,如饮食,益生菌和FMT,有望缓解ASD症状.
- 需要进一步的研究来澄清代谢物调节,并解决治疗反应的个体差异.
- 未来的研究应该整合多主题和人工智能,以实现个性化的ASD干预.
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