胃肠道疾病中的肠道微生物群调节:当前的证据和治疗前景
Meng-Ying Zhang1, Shao-Yu Chen2, Yu-Hua Lin3,4
1Department of Intervention, Shanghai Xuhui Central Hospital, Shanghai, China.
Frontiers in cellular and infection microbiology
|January 21, 2026
概括
功能医学利用肠道微生物组调制来个性化治疗胃肠道疾病. 诸如益生菌和便微生物群移植等干预措施在恢复平衡和改善健康方面表现有前途.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 功能医学是一种功能医学.
背景情况:
- 肠道微生物组显著影响胃肠道健康,并影响远处的器官.
- 微生物不平衡,特别是致病性细菌的主导地位,有助于胃肠道疾病.
- 超基因组学和代谢学等先进技术揭示了微生物组的系统性影响.
研究的目的:
- 审查肠道微生物群在胃肠道健康中的关键作用.
- 探索功能医学对胃肠道疾病的治疗潜力.
- 检查新兴干预措施,并比较跨疾病的方法.
主要方法:
- 关于肠道微生物组医学当前文献的综述.
- 临床试验和动物模型的分析.
- 探索新兴干预措施,如菌体疗法和工程微生物.
主要成果:
- 肠道微生物组调制表明在逆转胃肠道疾病方面具有治疗潜力.
- 诸如益生菌,FMT和SCFA等干预措施可以恢复微生物平衡并增强免疫力.
- 研究结果的变化需要进一步的标准化研究.
结论:
- 肠道微生物群对胃肠道健康至关重要,功能医学提供了有前途的个性化策略.
- 新兴疗法有可能恢复微生物平衡和治疗胃肠道疾病.
- 肠道微生物组调制方法的标准化对于广泛的临床应用是必要的.
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